Optimality criteria for futility stopping boundaries for group sequential designs with a continuous endpoint
نویسندگان
چکیده
منابع مشابه
Choice of futility boundaries for group sequential designs with two endpoints
BACKGROUND In clinical trials, the opportunity for an early stop during an interim analysis (either for efficacy or for futility) may relevantly save time and financial resources. This is especially important, if the planning assumptions required for power calculation are based on a low level of evidence. For example, when including two primary endpoints in the confirmatory analysis, the power ...
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ژورنال
عنوان ژورنال: BMC Medical Research Methodology
سال: 2020
ISSN: 1471-2288
DOI: 10.1186/s12874-020-01141-5